I thought there was a sump.Matt, I think that's a typo.......46G bow, no sump, 100# LR, 60# LS, I don't think there's 40 total gallons in the system.
How about 20?
Regardless, in an established tank, I assert that you can safely change 80% of the system water. With 100lbs., basically all of your microbial community is going to be present on the rock. Just make sure you match temperature, salinity, and pH as exactly as possible when doing such large water changes.
So basically, my advice becomes leaving maybe 3" of water over the sand bed and changing out the rest twice with two weeks in between.
Matt